Aim: There has been using natural flax fiber and biodegradable polymers due to their environmental sustainability. The use of natural flax fiber the fabrication is done and the delamination factor is tested in CNC and it is drilled by using Carbide Tipped Drill (8 mm). This study aims to Compare delamination factor in CNC drilling  of Novel Flax Fibre-reinforced aluminum wire mesh sandwich composite and Flax Fibre laminate with 90⁰/0⁰/90⁰ ply orientation angle Materials and Methods: The work material is chosen for this study is Aluminum wire mesh of grade 6092 and flax fiber. The type of drill bit selected for drilling operation is Tungsten Carbide Tipped drill bit. Two input parameters considered are cutting speed (m/min) and feed rate (mm/rev). Two groups of experimental study are selected with 20 samples per group and delamination factor is measured for all the samples and the average is utilized for roughness calculation. On the whole 40 samples are collected and measured for 2 groups with g-power 80% used for calculating sample sizes. Results: The delamination factor obtained during the study is measured and analyzed. All the results obtained were analyzed for their significance by SPSS software and the graphs were plotted and the level of significance was found to be 0.024 (p<0.05). Conclusion: Within the limitations of this study, the analysis of flax fiber laminate with (90^o/0^o/90^o) ply orientation angle has produced a delamination factor of  of 1.1370 for the samples reinforced with Aluminium mesh and the mean delamination factor of 1.2045 for samples reinforced without Aluminium mesh with an improvement of 5.9% in reducing delamination factor comparing base materials.