In the present research, this question has been considered, "What are the factors that cause major problems in the way of negotiations between Iran and the United States? “which in response it can be stated that factors causing major problems regarding the mentioned way are the non-proliferation lobby, the human rights lobby, the financial affairs lobby, the regional and global lobby, the set of Israeli lobbies, the pressure groups and the competition between the poles of power. Moreover, it should be noted that there are three scenarios that determine the range of possibilities for the outcome of the negotiations between Iran and the United States, and based on that, the result of the negotiations can be something between these two options of the failure of the negotiations or a weak agreement (regardless of the JCPOA) and the revival of the JCPOA in its current form or a stronger and longer agreement (JCPOA Plus). Additionally, if the aforementioned fundamental problems cause the failure of negotiations between Iran and the United States, based on the possible scenario that was examined in the research, Iran's economic and political environment will continue to exist like the current situation, maybe a little weaker and stricter, and the challenges for the country will be intensified. In this research, by accepting the principles of the interpretative qualitative method, the problems of negotiations between the Islamic Republic of Iran and the United States were studied futuristically, and the method of this research is the extension of the present to the future and the construction of the future, which is considered one of the methods of futuristic research. The research strategy is the questionnaire and the type of research is applied study, case study, and trend study.