This study aims to identify the mean values of self-esteem, educational stress, and depression, to examine the correlations between them, and to identify their contributing factors among students in high school within the context of e-Learning during the covid-19 outbreak. Across sectional design was utilized in this study. A convenience sampling technique was used to select 1380 students from four public schools in Amman, Jordan. A self[1]administered questionnaire was utilized to collect the data from the students. The descriptive and inferential analyses were carried out using the Statistical Package for Social Sciences (SPSS) version 21 software. The results showed that the mean values of the mean self[1]esteem, educational stress, depression level were moderate (mean=32.21/50, SD=5.41; mean=21.72/35, SD=5.27; mean=11.86/18, SD=3.27). The results showed a significant negative correlation between self-esteem and education stress (r=-.157, p value= .01) and depression ((r=-.094, p value= .04) and a significant positive correlation between education stress and depression (r=-.129, p value= .02). Finally, gender, receiving the private course, satisfaction with e-learning, and religiosity factors are considered predictors for self-esteem, educational stress, and depression among students in high schools. Self-esteem, educational stress, depression level are important variables affecting the students' wellbeing in high school. Many students' characteristics may affect these variables.