Human trafficking, especially the trafficking of women and children, is a criminal act that must be eradicated. Women and children are targeted by traffickers for purposes such as prostitution, sexual exploitation, pornography industry, drug trafficking, organ trafficking, and other forms of exploitation. Therefore, legal protection against the crime of human trafficking is crucial for women and children in Indonesia. The objective of this research is to explore the importance of legal protection for women and children from the crime of human trafficking in Indonesia. The research method employed is normative juridical. Normative juridical is a method in normative legal research that analyzes secondary data. The secondary data was condensed through literature review, and then qualitatively analyzed using a juridical approach. The findings of this research are as follows: Legal protection for women and children from the crime of human trafficking should be supported not only by legal substance in the form of legislation but also by other components, namely legal structure, which includes law enforcement agencies, and legal culture or societal support. Support from legal substance, legal structure, and positive legal culture is crucial in providing effective legal protection for women and children from the crime of human trafficking. All these aspects are interconnected and mutually influential. Without adequate legal substance, an effective legal structure would be difficult to achieve, as well as without supportive legal culture. Conversely, without a supportive legal culture, the implementation of legal substance and good legal structure would also face obstacles.