Lecturers are professional educators from scientists with the main task of transforming, developing and disseminating science, technology and arts through education, research and community service. The task of tridharma must be carried out properly and correctly, so the performance of lecturers is one of the concerns of universities and even the community. This study used a survey method using a sample of 168 university lecturers in the Cilacap Regency area as research respondents. Obtained the results of the study there is the influence of work motivation on OCB (organizational citizenship behavior), there is the influence of work motivation on lecturer performance mediated by OCB (organizational citizenship behavior) there is the influence of OCB (organizational citizenship behavior) on performance, there is the effect of work fatigue on OCB (organizational citizenship behavior), There is an effect of work fatigue on performance, there is an effect of work fatigue on lecturer performance mediated by OCB (organizational citizenship behavior) on lecturers in Cilacap Regency Based on the results of the study it is suggested to improve the performance of the lecturers needed motivation, reduction of fatigue so that they can work comfortably. OCB is one of the bridges or the media so that the performance of lecturers is improved.